Timmy! and the Lords of the Underworld
In the "Timmy 2000", episode (April 19, 2000) of animated comedy television series South Park, handicapped classmate Timmy happens upon a garage metal band called Lords of the Underworld, and even though Timmy can only scream his name and nothing else, he fits right into the group as lead singer.
Together, they win a Battle of the Bands contest allowing them to open for Phil Collins at the Lalapalalapaza festival, but guitarist Skyler gets jealous of Timmy's fame and quits the band. While Collins performs at the fest, the audience boos him offstage and the reunited Timmy and the Lords take over as headliners. They perform their only song, "Timmy and the Lords of the Underworld," which can be played on Rock Band.